Finding that special hotel for your holiday needs to be a carefully considered decision if your vacation is to be a memorable one. As part of our guide to luxury hotels in Napa Valley Region we have combined the major worldwide luxury hotel chains with some of the best hotels in Napa Valley Region that are independently managed or owned by small chains with just a few hotels in their portfolio. If you would like to search for a hotel by specific hotel chain, you can view our Hotel Chains section where we've listed a number of the luxury hotel chains within a single section.